Author

Salma M. Hefny

2 papers indexed here

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Open access Aug 2026

Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity

A new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronou...

Wagdy M. Eldehna, Ashraf K El-Damasy, Jaeyeop Lim et al. · RSC Advances · 1 citation

Review Sep 2026

Mutant isocitrate dehydrogenase in cancer: Structural biology, small-molecule inhibitors, and future drug discovery strategies.

Isocitrate dehydrogenase (IDH) enzymes convert isocitrate to α-ketoglutarate. When IDH1 or IDH2 is mutated, the enzyme gains a new function, and the oncometabolite D-2-hydroxyglutarate (D-2-HG) accumulates. Its epigenetic and metabolic effects depend on the tumor context. This review classifies mutant IDH inhibitors by...

Moataz A. Shaldam, Anwar A. El-Hamaky, Nourhan A. Khattab et al. · Drug Discovery Today · 0 citations