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Saman Gharehnaghadeh

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Open access Oct 2026

Click-engineered codeine derivatives: modulating pharmacological activity via 1,2,3-triazole tethering.

The structural modification of morphinan alkaloids remains a vital strategy for developing therapeutics with optimized efficacy and reduced side effects. Herein, we report the rational design and synthesis of a novel library of seventeen 1,4-disubstituted 1,2,3-triazole-tethered codeine derivatives (13a-13q). Utilizing...

Saman Gharehnaghadeh, Peyman Salehi, Morteza Bararjanian et al. · 0 citations

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