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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Samantha Gies

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2 papers indexed here

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Open access Aug 2026

Dimer opening enables brain-type creatine kinase to sense membrane curvature

Brain-type creatine kinase (CK-BB) buffers local ATP demand through reversible phosphotransfer between ATP and phosphocreatine, yet how this soluble metabolic enzyme engages membrane compartments is unknown. Here, we combine fluorescence microscopy, DEER spectroscopy, hydrogen–deuterium exchange and native mass spectro...

Samantha Gies, Nolan K. McLaughlin, O. Kou et al. · 0 citations
Open access Aug 2026

Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter

Spns transporters are a mechanistically distinct branch of the major facilitator superfamily that regulate lipid transport, lysosomal homeostasis, immunity and disease, yet how the conserved Spns fold integrates protonation, substrate binding and alternating access to support chemically and directionally diverse transp...

Reza Dastvan, Samantha Gies, Kevin L. Jagessar et al. · 0 citations

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