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Author

Samantha R. McDonough

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Review Open access Sep 2026

Autophagy-lysosomal pathway in neurodegeneration

Dysregulation of ALP-associated processes, including autophagic flux, chaperone-mediated autophagy, endolysosomal trafficking, lysosomal pH and ion balance, and lysosomal metabolic signaling, is implicated in both the pathogenesis and progression of neurodegenerative diseases, with an emphasis on Alzheimer’s disease an...

Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer et al. · 0 citations

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