Microglia regulate synaptic remodelling, eliminating weakened and dysfunctional synapses to maintain circuit development and homeostasis. Adhesion G protein-coupled receptor G1 (ADGRG1/GPR56) has emerged as a distinctive regulator integrating phosphatidylserine recognition, mechano-transduction, and G-protein signallin...
Akshay K. Chaudhari, Sameer N. Goyal· Biochimica et biophysica act...· 0 citations
Neuropsychiatric conditions such as depression, anxiety, and stress-related disorders are increasingly associated with Polycystic Ovary Syndrome (PCOS). Evidence suggests that these conditions are not only linked to the metabolic features of PCOS but also share common underlying mechanisms, including hormonal imbalance...
Kamini R. Shirasath, Sanjay N. Awathale, Sameer N. Goyal· Journal of Psychiatric Resea...· 0 citations
Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder involving neuroinflammation, glutamatergic dysregulation, and altered calcium signaling. Our recent work identified transient receptor potential melastatin 3 (TRPM3) channels as key contributors to OCD pathogenesis via modulation of neuroinflamm...
Prerana V Chaudhari, Sanjay N. Awathale, Sachin R. Ahire et al.· European Journal of Pharmaco...· 0 citations
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