Author

Samuel A. Myers

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Open access Sep 2026

IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage

CD4+ cytotoxic T lymphocytes (CD4-CTLs) are understudied immune mediators with ambiguous origins. Despite expressing RUNX3, granzyme B (GZMB), and perforin (PRF1), CD4-CTLs are frequently classified as Th1 extensions due to shared interferon-γ (IFNγ) and T-BET expression. Here, we identify interleukin-27 (IL-27) as a i...

M. Matias, R. Marrocco, Kyle Magro et al. · bioRxiv · 0 citations

Open access Aug 2026

A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo

The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanism for switching between these two opposite polarity microtubule motors remains unknown. Here, we coupled a cellular synt...

C. Gladkova, Maria G Paez-Segala, W. Grant et al. · Science · 0 citations