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Author

Samuel A. Rose

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2 papers indexed here

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Sep 2026

Abstract PR005: The basal cell state maintains pancreatic cancers by controlling an immunosuppressive cell circuit

Intratumoral heterogeneity is a defining feature of pancreatic ductal adenocarcinoma (PDAC), yet how distinct malignant cell states contribute to tumor behavior and stromal diversity in situ remains poorly understood. PDAC contains recurrent classical and basal states, with basal-dominant tumors associated with aggre...

Kate Ryan, A. Singhal, Samuel A. Rose et al. · 0 citations
Open access Sep 2026

Dendritic cell PD-L2 restrains intratumoral CD8+ T cell immunity

Blockade of inhibitory PD-1 signaling on T cells is a cornerstone of cancer immunotherapy, with current strategies targeting PD-1 or its ligand PD-L1. However, PD-1 engages an alternative ligand, PD-L2, whose role in tumor immunity remains poorly defined. Here, we show that PD-L2 is upregulated on intratumoral CCR7⁺ co...

Jinwoo Nah, Amanda Sun, Anushka Yadav et al. · 0 citations

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