Author

Samuel B. Warner

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Open access Sep 2026

An altered B cell compartment distinguishes low antibody responders among people with HIV

Chronic HIV infection can leave persistent immune dysregulation despite effective antiretroviral therapy (ART), but how this altered immune landscape affects antibody induction and durability after antigen exposure remains unclear. We used SARS-CoV-2 infection and vaccination as a model of humoral immunity to a novel a...

Karli R. Redinger, Samuel B. Warner, A. Jamal et al. · medRxiv · 0 citations

Open access Jul 2026

CpG-Adjuvanted Heplisav-B Induces Strong Th1-Biased Innate Responses Compared to Alum-Adjuvanted HBV Vaccines in PLWH 2308661

Alum-adjuvanted HBV vaccines such as Engerix-B offer limited protection for people living with HIV (PLWH), achieving only 35—70% seroprotection (as defined by HBsAb titers ≥10 mIU/mL). While Heplisav-B’s CpG 1018 adjuvant improves immunogenicity in PLWH, its mechanisms for overcoming HIV-related immune dysfunctio...

Jenny M. Lee, Prasanthy Balasubramanian, Yufeng Liu et al. · Journal of Immunology · 0 citations