Author

Samuel J. Guzman

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Open access Sep 2026

Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus

Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling mediates delirium-like phenotypes in a murine VILI model. H...

Kevin D. Winzey, Samuel J. Guzman, Edward Yang et al. · Intensive Care Medicine Expe... · 0 citations

Open access Aug 2026

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

It is hypothesized that upstream alterations in these two pathways contribute to hippocampal dysfunction in DS‐AD.

Abigail J. Nordbeck, Mitchell Martá-Ariza, Henric Ek Olofsson et al. · Alzheimer's & Dementia · 0 citations