Sana Nakamae

Increasing global chromatin accessibility alone is insufficient to enhance global transcription during mouse zygotic gene activation.

In mice, zygotic gene activation (ZGA) occurs in two waves: a minor wave at the 1-cell stage and a major wave at the 2-cell stage. At the 1-cell stage, chromatin is highly decondensed and transcriptionally permissive; however, global transcription is low. At the 2-cell stage, global transcription increases with chromat...