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Author

Sanam Shahid

2 papers indexed here

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Open access Nov 2026

An information-theoretic framework for inferring T cell dynamics from single-cell RNA and T cell receptor sequencing.

Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...

N. Ceglia, Sohrab Salehi, Z. Sethna et al. · 0 citations
Open access Oct 2026

Engineered NKG2C+ CD8+ TKLR cells exhibit effective antitumor control in mice while mitigating cytokine release syndrome.

Engineered T and NK cell therapies have widely been used to treat hematologic malignancies and solid tumors, with promising clinical results. Current chimeric antigen receptor (CAR) T cell therapeutics are, however, associated with treatment-related adverse events such as cytokine release syndrome (CRS) and are prone t...

Kyle B. Lupo, M. Panjwani, Aya G. Halawi et al. · 0 citations

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