Integrated computational evaluation of novel benzimidazole scaffolds as dual COX-2 inhibitory and histamine H1 antagonistic activity
Chronic inflammatory and hypersensitivity diseases are regulated by linked biochemical pathways where cyclooxygenase-2 (COX-2) and histamine H1 receptor are vital therapeutic targets. The current study sought to produce and computationally screen emerging benzimidazole derivatives as dual-acting agents with prime pharm...