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Author

Sandip B. Bharate

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Sep 2026

A Thieno[3,2-D] pyrimidine class of p110α/GDH1 dual inhibitor SBS-873 suppresses TNBC growth by inhibiting PI3K/mTOR signaling and inducing ferroptosis through glutathione depletion.

BACKGROUND Genetic alterations in phosphoinositide 3-kinase (PI3K) signaling are frequently observed in triple-negative breast cancer (TNBC), with the p110α subunit being the most mutated. Although this identifies p110α as a promising therapeutic target, selective inhibitors have demonstrated limited efficacy. Therefor...

Biswajit Dey, Essha Chatterjee, Sivkan Kaur Nanda et al. · 0 citations
Aug 2026

Pharmacological inhibition of CDK7 and CDK9 suppresses gastrointestinal (colon) cancer progression through modulation of stemness, epithelial-mesenchymal transition, and chemoresistance.

GNE-3511 exerts potent anticancer activity by disrupting CDK7/9-dependent transcriptional programs that regulate proliferation, apoptosis, stemness, EMT, and multidrug resistance and is identified as a potential lead candidate for the treatment of colorectal cancers.

Nidhi Sharma, Suriya Panneerselvam, Sandip B. Bharate et al. · 0 citations

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