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Author

Sandra H. Jacinto

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Open access Sep 2026

SMRT regulation of nuclear receptors orchestrates bile acid homeostasis

Nuclear receptors are key effectors of metabolic programs; however, the contribution of co-regulatory complexes in maintaining metabolic homeostasis is not fully understood. Here, we show that modulation of the constitutive androstane receptor (CAR) by the co-repressor silencing mediator of retinoic acid and thyroid ho...

Kyeongkyu Kim, S. Fang, Suk-hyun Hong et al. · 0 citations
Review Open access Aug 2026

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo

Enhancers control tissue-specific gene expression across animals1. Although deep learning2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms4, 5, 6, 7, 8, 9–10 (reviewed in a previous publication11), it remains unclear whether such approaches can operate within the r...

Shen-Zhi Chen, Vincent Loubière, Ethan W. Hollingsworth et al. · 1 citation

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