Open access
Aug 2026
CSTF2-mediated 3′UTR shortening drives oncogenic activation of GPC3 in hepatocellular carcinoma
Alternative polyadenylation (APA) generates mRNA isoforms with distinct 3′ untranslated regions (3′UTRs), thereby influencing transcript stability and translation. In cancer, 3′UTR shortening can activate oncogenes by escaping microRNA (miRNA)-mediated repression, but its role in hepatocellular carcinoma (HCC) remains...
Soyoung Jeon, Eunbi Shin, Woong-Ha Jin et al.
· Oncogene · 0 citations