Open access
Aug 2026
Phenotype-associated spatial biomarker discovery in spatial transcriptomics with spHOT
Spatial transcriptomics now profiles patient cohorts at single-cell resolution, enabling analysis of disease-associated cell organization in situ. However, discovering such spatial biomarkers remains challenging because relevant structures occur at unknown scales and cell-or niche-level annotations are rarely available...
Hoeyoung Kim, Donghee Kim, Sangwook Jung et al.
· bioRxiv · 0 citations