Santhosh Kumar Nadikatla

Green synthesis of N-aryl-1-(2-bromo-4-methyl phenyl)-1H-tetrazol-5-amines as novel anti-cancer agents targeting tubulin-Combretastatin A4 complex and human non-small cell lung cancer cell lines.

A series of N-aryl-1-(2-bromo-4-methyl phenyl)-1H-tetrazol-5-amines was synthesized through a two-step microwave-assisted protocol from 2-bromo-1-isothiocyanato-4-methylbenzene and substituted aryl amines. Initially, thiourea derivatives were prepared under solvent-free microwave conditions, followed by cyclization wit...