Open access
Aug 2026
Mapping the NFYA 3′UTR landscape identifies alternative polyadenylation as a targetable vulnerability in prostate cancer
Findings establish NFYA 3′UTR lengthening in PCa cells via CRISPR/Cas9 or ASOs diminished NF-YA protein levels and suppressed aggressive tumor traits both in vitro and in vivo, and provide proof-of-concept for gene-specific, APA-directed therapeutic strategies.
Giulia Pagani, Chiara Casirati, Cecilia Pandini et al.
· Journal of Experimental &... · 0 citations