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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Sarah E. Coupland

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3 papers indexed here

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Open access Sep 2026

Deep Learning Classification of Uveal Melanoma and Metastatic Carcinoma on Cytology Specimens: A Single-Center Experience

Purpose Differentiating between a choroidal melanoma and metastatic carcinoma to the choroid on cytological specimens presents significant diagnostic challenges due to subtle morphological differences in the sparse cells available in the sample and the increasing scarcity of specialist ocular pathologists. This study d...

Maxine Jackson, H. Kalirai, Rumana N. Hussain et al. · 0 citations
Open access Sep 2026

Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations

Summary Uveal melanocytes are neural crest-derived cells contributing to ocular pigmentation, yet their developmental heterogeneity and microenvironmental roles remain poorly characterized. We present a single-cell transcriptomic atlas of the human fetal uveal tract, profiling 81,603 cells across 14 cell types from eig...

J. Draper, I. Reekie, Lakshanie C. Wickramasinghe et al. · 0 citations
Open access Aug 2026

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

It is demonstrated that inhibition of these protein kinases significantly suppresses the growth of UM spheroids exposed to both X-rays and PBT, which is primarily driven by delayed and persistent DSBs, leading to the accumulation of chromosomal aberrations.

Laura Hawkins, R. Morris, H. Kalirai et al. · 0 citations

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