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Author

Sarah J. Marzi

2 papers indexed here

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Review Open access Sep 2026

Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders.

Determining the optimal timing of disease-modifying therapies for neurodegenerative disorders will necessitate identification of when the underlying pathobiological process becomes active, well in advance of the point at which clinical manifestions appear. Phenoconversion, the emergence of clinically manifest syndomes,...

Michael J. Strong, Neil S. Donison, A. Al-Chalabi et al. · 0 citations
Open access Sep 2026

Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia

Alzheimer’s disease (AD) is characterised by aberrant amyloid beta and tau aggregation, neuroinflammation, demyelination and neurodegeneration, which have been linked to changes in cell-specific gene expression signatures. Among the mechanisms driving cell-type-specific transcriptional changes, histone acetylation play...

Charbel Gergian, Paulina Urbanaviciute, Philippa M. Wells et al. · 0 citations

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