Sarah K. Engel

Tau Protein Aggregation Kinetics, Seed-Competent Species Identification, and Inhibition by Small-Molecule Stabilizers of the Tau R3 Microtubule-Binding Domain

This study investigates tau R3 domain aggregation nucleation kinetics, seed-competent oligomer characterization, and small-molecule stabilizer inhibition of tau fibrillization in vitro within the context of neurobiochemistry and Alzheimer's disease drug discovery, an area of growing scientific importance given its impl...