Author

Sarah L. Allinson

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Review Open access Sep 2026

On-DNA photochemical methods for expanding DNA-encoded library (DEL) chemical space

DNA-encoded libraries (DELs) have become a mainstay of small-molecule discovery, enabling millions to billions of compounds to be screened in a single pooled affinity selection in which each small molecule is covalently linked to a unique DNA identifier. However, the chemistry available for their construction remains l...

Oliver J. Corrigan, Sarah L. Allinson, Jamie H. Docherty · RSC Medicinal Chemistry · 0 citations

Review Open access Jul 2026

Recent Progress in Targeting Kinases Involved in the DNA Damage Response for the Treatment of Cancer

The current ATM, ATR, DNA-PK, CHK1, CHK2 and WEE1 inhibitors that show the most promise as monotherapies and combination treatments in solid tumours are discussed, as well as the potential benefits of using TPD technology over small-molecule inhibitors.

Lauryn Buckley-Benbow, Antonia M. Rout, Andrew B. Fielding et al. · TARGETS · 0 citations