Sarah N. Ruckman

Selection on cuticle color produces a genome-wide response that does not localize to known major genes in Drosophila

Complex traits are often deemed highly polygenic when a mapping study fails to localize the loci underlying them, but a result that fails to identify major genes can also reflect a lack of power. Cuticle color in Drosophila offers a natural test of this distinction, since genes of large effect segregate in natural popu...