Sarah Naiyer

YY1 regulates B cell lineage plasticity via transcriptional, miRNA post-transcriptional, and epigenetic mechanisms 2299696

YY1 is essential for embryogenesis, cell proliferation, and lineage differentiation. It regulates genes via co-activators, co-repressors, or PcG complexes. In hematopoiesis, YY1 controls stem cell differentiation, and its loss at the pro-B stage halts B-cell development. Bulk RNA-seq of WT and YY1-KO pro-B...

miRNA-mediated regulation of lineage plasticity in YY1 knockout pro-B cells

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.

Marginal zone (MZ) B cells optimize protection against blood-borne bacteria by rapidly producing plasma cells in response to Toll-like receptor (TLR) ligands. Here, we demonstrate that Notch2 instructs this responsiveness for both the dsRNA sensor TLR3 and LPS sensor TLR4. Using mathematical modeling of cell trace time...