Sarah Ragab Abd El-Khalik

Mechanistic Insight into the Role of Maresin-1 in Attenuating Lithium-Induced Nephrogenic Diabetes Insipidus in Rats via Regulation of cAMP/AQP2 Signaling and SERCA2b Dependant Endoplasmic Reticulum Stress.

BACKGROUND Nephrogenic diabetes insipidus (NDI), one of the common complications of chronic administration of lithium, is characterized by severe urine concentrating defects. It is associated with aberrant regulation of aquaporin-2 (AQP2) proteins as well as endoplasmic reticulum (ER) stress. Therefore, we evaluated re...