Author

Sarah T. Diepstraten

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Open access Sep 2026

A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

CRISPR activation (CRISPRa) enables precise up-regulation of gene expression for ex vivo and in vivo applications. However, a lack of scalable, high-coverage tools has limited comprehensive genetic screening in murine models. Here, we introduce Partita, a next-generation mouse whole-genome CRISPRa sgRNA platform, desig...

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts et al. · Science Advances · 0 citations

Open access Sep 2026

γδ T cells modulate anti-tumor immunity in small cell lung cancer.

Small cell lung cancer (SCLC) is a highly aggressive neoplasm with limited sensitivity to anti-PD-(L)1 blockade, which is likely caused by the epigenetic silencing of MHC-I. Elucidating MHC-I-independent immune recognition mechanisms is therefore crucial for enhancing treatment responses and improving clinical outcomes...

Jin Ng, Yue You, Tina Zhang et al. · Cancer Cell · 0 citations