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Author

Sarra B. Shakartalla

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Review Open access Sep 2026

Purine nucleoside phosphorylase in breast cancer from metabolic regulation to targeted therapy: challenges and opportunities.

The rational design of selective inhibitors with improved pharmacokinetic profiles, combined with biomarker-driven patient stratification and combination therapy strategies, establishes a strong rationale for the development of clinically effective PNP-targeted therapies for breast cancer.

Sahar Salem, R. Hamdy, Sarra B. Shakartalla et al. · 0 citations

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