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Saruby Sharma

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Open access Sep 2026

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase–nuclease coupling

RNA degradation shapes cellular and organellar gene expression. In human mitochondria, this process is mediated by a dedicated degradosome comprising the helicase SUV3 and the exoribonuclease PNPase, but how these enzymes assemble and cooperate to degrade structured RNA has remained unknown. Here, we report the cryo-EM...

P. F. V. Do Prado, Saruby Sharma, Arjun Bhatta et al. · 0 citations

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