Author

Sathiyabama Ramanujam

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Open access Aug 2026

Genomic exploration and in silico prioritization of putative COX-2-targeting metabolites from Streptomyces sp. VITGV156 (MCC 4965)

Introduction Streptomyces species represent an important source of bioactive natural products, yet systematic genome-guided prioritization of metabolites targeting cyclooxygenase-2 (COX-2/PTGS2) remains limited. This study aimed to investigate the biosynthetic potential of Streptomyces sp. VITGV156 (MCC 4965) using an...

Veilumuthu Pattapulavar, Saranyadevi Subburaj, Sathiyabama Ramanujam et al. · Frontiers in Bioinformatics · 0 citations

Review Open access Aug 2026

Molecular biology and integrated strategies for activating cryptic biosynthetic gene clusters toward next-generation antibiotic discovery

The biological relevance and evolutionary advantage of cryptic BGCs’ role in interactions between microorganisms, such as competition, communication, symbiosis and environmental adaptability, are discussed to provide a useful background for accelerating next-generation antibiotics.

Veilumuthu Pattapulavar, Sathiyabama Ramanujam, Avanthi Yellampalli et al. · Frontiers in Bioinformatics · 0 citations

Review Open access Aug 2026

Beyond antibiotics: artificial intelligence–enabled anti-infective ecosystems for next-generation precision therapeutics against antimicrobial resistance

The Intelligent Anti-Infective Ecosystem (IAIE) is proposed as a conceptual systems-level framework that computationally integrates multimodal diagnostics, pathogen genomics, microbiome profiling, AI-assisted decision support, programmable precision therapeutics, ecological monitoring, and longitudinal clinical feedbac...

Veilumuthu Pattapulavar, Sathiyabama Ramanujam, Rosshini Badmanathan et al. · Frontiers in Cellular and In... · 0 citations