GLS2 Promotes Early Ferroptosis Followed by Apoptosis and p53 Signaling in Renal Ischemia-Reperfusion Injury.
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), particularly in the settings of kidney transplantation and perioperative care. In IRI-induced AKI, ferroptosis, an iron-dependent, lipid peroxidation-driven form of regulated cell death, occurs early in proximal tubular epithelial ce...