Open access
Aug 2026
Determinants of functional burden pleiotropy and gene dosage responses across human traits
Pleiotropic and monotonic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are not well characterized. Here we develop a functional burden analysis to investigate the association of all protein-coding copy-num...
Sayeh Kazem, Kuldeep Kumar, J. Yang et al.
· Nature Communications · 0 citations