Sean A. Gile

Ten Non-N-Terminal-Domain Inhibitors of the Hsp90 Chaperone Machine Fail to Elicit Canonical Proteome-wide Responses in Jurkat Leukemia Cells.

Heat shock protein 90's (Hsp90) roles in cancer have prompted the development of small-molecule inhibitors that target its N-terminal ATP-binding pocket. Moreover, numerous alternative Hsp90 inhibitors (AHI) have been developed to target other sites of the Hsp90 chaperone complex. Alternative Hsp90 inhibition is typica...