Author

Sean Cottrell

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Preprint Sep 2026

Data-Adaptive Grassmann Manifold Representations for Spatial Transcriptomics Alignment

Spatial transcriptomics measures gene expression together with spatial coordinates, but many existing analysis methods represent each spot primarily by a single feature vector. We propose GrassST, a subspace method for spatial transcriptomics analysis and cross-slice alignment. For each spatial spot, GrassST constructs...

Xiang-Xiang Wang, Sean Cottrell, Guo-Wei Wei · 0 citations

Open access Aug 2026

Peptide tiling across viral proteomes identifies modular regulators of stress-induced cell death

A pooled peptide tiling approach was applied to systematically identify compact viral protein regions that alter cell death and support a model in which viral proteins encode modular host-regulatory functions and establish peptide tiling as a scalable framework for functional annotation across viral proteomes.

Jaice T Rottenberg, Ezra Taub, Sean Cottrell et al. · bioRxiv · 0 citations