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Preprint Sep 2026

GIA: Germline-Informed Aging with AlphaGenome Finds Genetically Regulated CpGs

Epigenetic clocks estimate age and aging-related phenotypes from DNA methylation at selected CpG sites, but the extent to which these inputs are influenced by germline genetic variation is unclear. Because methylation at many CpGs is genetically regulated, some between-person variation in clock estimates may reflect in...

Sean Lim · 0 citations

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