Sebastian Porsdam Mann

From Single Cells to Diagnosis: Proteomics Technologies in the Multi‐Omics Landscape of Rare and Mitochondrial Diseases

Proteomics by mass spectrometry has rapidly matured from a niche method into a standard tool. The recent 10‐year trajectory of single‐cell proteomics has opened a new biological dimension for studying disease. Mitochondrial diseases, with their pronounced cell‐to‐cell heterogeneity, are particularly, well‐suited to the...

Large Language Model Few-Shot Prompting with Dilemma Training Outperforms Human Surrogates in Predicting Patient Preferences

In serious illness, human surrogates often struggle to accurately predict patient preferences (68% accuracy), causing decision conflict. Personalized Patient Preference Predictor (P4) agents offer a potential solution, but prior prototypes treat values as static ratings, ignoring the contextual, situation-dependent nat...

Imaginative Vulnerability and Symbolic Mediation: A Phenomenological Analysis in Schizophrenia-Spectrum Conditions.