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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Seitaro Takahashi

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Sep 2026

Synthesis, Chemical, and Biological Evaluation of Actinomycin Tetracyclic Oxazinone Derivatives and Application to Small-Molecule Drug Conjugates

Actinomycin D (1) is a chromopeptide antibiotic natural product used in the treatment of various malignancies, although its clinical use is limited by high toxicity. Tetracyclic actinomycin oxazinone derivatives have been reported to generate 1 through hydrolysis under physiological conditions, but detailed mechanist...

Seitaro Takahashi, Kenta Asao, Satoshi Ichikawa · 0 citations

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