G-protein-coupled receptors (GPCRs) are essential mediators of cellular processes, and their dysfunction is implicated in various diseases. Although pharmacological approaches are powerful for elucidating GPCR functions, careful consideration of potential off-target effects remains crucial. Here, we present an off-targ...
Yuma Matsuoka, Hajime Inoue, Tatsuki Hori et al.· Cell Chemical Biology· 0 citations
RNA splicing is a post-transcriptional modification process of precursor mRNA. This process is regulated by the macromolecular complex known as the spliceosome. One of the major components of spliceosomes is the small nuclear ribonucleoprotein (snRNP). Snrpf encodes SmF, a core protein component of the snRNP. Although...
Ho Tam Nguyen, Natsuki Mikami, K. Matsumoto et al.· Experimental animals· 0 citations
The findings show that the effects of an LMX1B variant cannot be predicted from its residual activity alone, and the susceptibility of each organ may depend on the cellular and genetic context in which the variant acts.
T. Amano, Keisuke Yoshida, F. Sultana et al.· bioRxiv· 0 citations
Whether frameshift-dominant targeting of exon 1 of Fgf10 is sufficient to generate a null allele of Fgf10, a gene essential for limb formation, is tested and it is found that exon 1 targeting did not reliably produce null phenotypes.
Khanui Lkhagvadorj, Eiichi Okamura, Toshifumi Morimura et al.· Journal of Developmental Bio...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
