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Sekhar Surapaneni

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Open access Jul 2026

SLC15A4 Inhibition by NTX-348 Suppresses Endolysosomal Toll-like Receptor Signaling, IRF5 Activation, and Type I Interferon Induction 2249463

In vitro studies show that SLC15A4 inhibition results in the intracellular degradation of the TASL adapter protein and blockade of inflammatory cytokine production in response to TLR7/8/9 agonists, and these results highlight the early progress developing novel, drug-like inhibitors of SLC15A4.

J. McElwee, Ana Antić, A. Basavapathruni et al. · 0 citations