Seohyun Choo

Ageing of the skeletal muscle as a barrier to cell therapy: Cell sources, microenvironmental failure and autologous alternatives.

The progressive decline of skeletal muscle (SkM) regeneration is a central feature of ageing. In sarcopenia, the age-related loss of muscle mass and function is driven by exhaustion and dysfunction of resident muscle stem cells and by degenerative remodeling of their regenerative niche, including cellular senescence, c...