Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives for GPR119 Agonistic Activity
GPR119 is a promising target for the treatment of type 2 diabetes mellitus. Stimulating this receptor leads to the induction of glucose-dependent insulinotropic peptide and glucagon-like peptide 1, which improves systemic glucose homeostasis. Encouraged by our previous research, we replaced 5-nitropyrimidine with 1,3,5...