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Serge Weis

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Open access Oct 2026

Epigenome-Wide DNA Methylation Profiling of Matched Primary Breast Cancers and Brain Metastases Reveals Epigenetic Markers linked to Metastatic Progression: A Preliminary Study

Introduction Breast cancer represents the most prevalent malignancy among women globally, with a rising incidence of metastases to the central nervous system. The presence of brain metastases is associated with a poor prognosis, largely due to the limited availability of effective treatment modalities. Methods In this...

Beate Alinger-Scharinger, Georg Hutarew, Christoph Schwartz et al. · 0 citations
Open access Oct 2026

Intratumoral desmoplastic stroma in carcinoma brain metastases harbors stromal cells with a cancer-associated fibroblast (CAF)-like immunophenotype.

BACKGROUND Research on the tumor microenvironment of brain metastases (BM) has largely focused on immune response, while the intratumoral stromal compartment remains poorly characterized. In primary carcinomas, cancer-associated fibroblast (CAF) are intratumoral stromal cells that enable tumor progression. A subset of...

D. Bandke, Serge Weis, Andreas Gruber et al. · 0 citations

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