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Author

Sergey A. Samsonov

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Open access Sep 2026

Molecular recognition of glycosaminoglycans and their sulfated deep-sea bacteria-derived mimetics, diabolican and infernan, by RANK, RANKL and OPG.

Maintenance of bone function and remodelling is a strictly controlled physiological process that is modulated by bone forming and resorbing, mediated by osteoblasts and osteoclasts respectively. A signalling axis involved in controlling this process involves receptor activator of nuclear factor kappa B ligand, receptor...

J. A. Clark, K. Bojarski, J. Muñoz-García et al. · 0 citations
Aug 2026

Understanding Fibroblast Growth Factor-Heparan Sulfate Recognition by Molecular Dynamics Approaches.

It is concluded that, depending on the 6-O-sulfation pattern and the length of the oligosaccharide, either predominantly electrostatic interactions or a more complex interplay between electrostatic and hydrophobic interactions determines the specificity of the resulting protein-glycosaminoglycan complex.

Sergey A. Samsonov, A. Sieradzan, Avner Yayon · 0 citations

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