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Author

Seunghyun Ahn

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2 papers indexed here

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Sep 2026

Aurone Derivatives as Inhibitors of ERK Phosphorylation in HCC827 Non-Small Cell Lung Cancer Cells.

INTRODUCTION Non-Small Cell Lung Cancer (NSCLC) continues to be a primary contributor to cancer- related death, with limited long-term efficacy of current therapies due to resistance and tumor heterogeneity. Focusing on downstream signaling pathways, such as the EGFR-mediated MAPK/ERK pathway, represents a promising th...

Junekyu Han, Seunghyun Ahn, Euitaek Jung et al. · 0 citations
Sep 2026

6-(2-Hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3‑carbonitriles as novel reactive oxygen species-generating anticancer agents inducing ER stress and DNA damage in EGFR-mutant non-small cell lung cancer.

A series of twenty-one 6-(2-hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3‑carbonitrile derivatives (HBPs), incorporating a pyrazolo[1,5-a]pyrimidine scaffold with a Michael acceptor moiety, were designed and synthesized as novel reactive oxygen species (ROS)-generating anticancer agents. Following structural characterizat...

Jiseong Baek, Seunghyun Ahn, Heewon Kang et al. · 0 citations

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