Differential Effects of the Apelin Receptor Blockade by [Ala13]-Apelin-13 on Colonic Barrier Integrity and Hepatic Inflammatory Responses in Chemically Induced Colitis
The apelin receptor (APJ) is widely expressed throughout the body and plays important roles in the regulation of inflammation, oxidative stress, and tissue repair. Because APJ signaling is highly context dependent and may vary according to tissue type, inflammatory status, and ligand activity, its biological consequenc...