Targeted Delivery of NGF-Pretreated Schwann Cell-Derived Exosomes for Osteoporosis Therapy: Overcoming Pain while Enhancing Bone Formation.
Osteoporosis (OP) is a prevalent skeletal disorder characterized by decreased bone mass and increased fragility, leading to fractures and chronic pain. Nerve growth factor (NGF) plays a pivotal role in bone homeostasis and neuro-regeneration but paradoxically exacerbates pain. This study investigated the therapeutic po...