Shaan D. Shah

Prime Editing in Selected Disease Applications: Cancer Models, Primary Immunodeficiency, β-Hemoglobinopathies, HIV/CCR5, and Neurodegenerative Targets

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 transformed genome engineering by enabling targeted DNA cleavage, but double-strand breaks can generate heterogeneous repair products and larger genomic alterations. Prime editing is a search-and-replace genome-editing strategy that combines a Cas9...