Review
Open access
Jul 2026
Restoring Cancer Genomes: Functional Mutation Correction as a Platform for Precision Oncology
It is proposed that systematic reversal of cancer mutations represents a conceptual shift from observing mutational landscapes to actively testing their biological necessity and provides a scalable functional platform to stratify drivers, interrogate variants of uncertain significance, and refine precision diagnostics.
Pascal Wang, Shady Sayed, Frank Buchholz
· Human Gene Therapy · 0 citations