Adaptive laboratory evolution and proteomic insight on collateral sensitivity for meropenem in colistin-resistant Klebsiella pneumoniae
This study developed a unique panel of colistin- and meropenem-resistant K. pneumoniae cells representing the early, mid, and late stages of AMR emergence, and revealed that colistin-resistant pathogens became sensitive to meropenem during adaptation to colistin, representing CS, which was validated by the emergence of...