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Author

Shaimaa A. Shehata

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Oct 2026

Olea europaea leaf extract mitigates doxorubicin-induced hepatotoxicity associated with modulation of oxidative stress, inflammation, and apoptosis: Integrated biochemical, molecular, and histopathological evidence.

BACKGROUND Doxorubicin (DOX) is an effective antineoplastic agent whose clinical use is limited by hepatotoxicity. This study evaluated the hepatoprotective effects of Olea europaea leaf extract (OLE) in a rat model of DOX -induced hepatotoxicity. METHODS Thirty-two male Wistar rats were randomly assigned to four gro...

M. Ibrahim, A. Khalifa, Rania A. Galhom et al. · 0 citations
Open access Sep 2026

PLGA-Encapsulated Pterostilbene Mitigates Cadmium-Induced Nephrotoxicity in Rats by Modulating Oxidative Stress, Inflammation, and Apoptosis

Cadmium (Cd) is an environmentally pervasive toxic metal that accumulates in the kidney and promotes oxidative stress, inflammation, and apoptosis. This study evaluated the renoprotective effects of free pterostilbene (PTS) and PLGA-encapsulated PTS (PTS-PLGA) in male Sprague–Dawley rats with Cd-induced nephrotoxicity....

Fahd Alaajam, E. Elmorsy, Amro Duhduh et al. · 0 citations
Open access Aug 2026

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...

Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al. · 0 citations

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