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Author

Shan Gao

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Open access Sep 2026

Integrated stress response inhibition decouples cardiotoxicity from anthracycline chemotherapy while enhancing antitumor efficacy.

The clinical efficacy of anthracycline chemotherapeutics is severely limited by their dose-dependent cardiotoxicity, a condition lacking effective preventive strategies. We identify the maladaptive ATF4-dependent integrated stress response (ISR) program as a central driver of this pathology. In murine models, ISR inhib...

Si-Min Yang, Zheng-Yang Chen, Hong-Li Zhang et al. · 0 citations
Review Open access Sep 2026

Traditional Chinese medicine reprograms the tumor microenvironment to overcome EGFR-TKI resistance: mechanisms and therapeutic perspectives

This review focuses on TME-mediated EGFR-TKI resistance in NSCLC and appraises TCM interventions according to evidence type and directness and provides a conceptual framework for evaluating TCM-based combination strategies intended to attenuate EGFR-TKI resistance.

Yuan Yao, Shan Gao, Jun-Ping Wang · 0 citations

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